Posted on December 3, 2012 by Sitemaster
According to a message to its members issued today by the American Urological Association (AUA), the AUA and the American Society of Clinical Oncology (ASCO) are archiving their collaborative 2008 guideline entitled Use of 5-alpha Reductase Inhibitors for Prostate Cancer Chemoprevention.
This guideline has now been removed from the ?Clinical Guidance? section of the AUA?s website, but is still available in the ?Archived Guidelines? section. According to the message sent to the AUA members, ?This decision is in response to the U.S. Food and Drug Administration?s denial of the supplemental New Drug Application for dutasteride for prostate cancer chemoprevention? ? a denial issued by the FDA in late January 2011.
The AUA further recommends to its members that using 5-alpha reductase inhibitors (5-ARIs) like dutasteride and finasteride for prostate cancer prevention ?is not FDA-approved and should be performed with caution.? The message concludes by noting that 5-ARIs ?maintain an FDA-approved indication to treat symptomatic benign prostatic hyperplasia.?
The ?New? Prostate Cancer InfoLink believes that some urologists and urologist oncologists will continue to prescribe 5-ARIs for the prevention of clinically significant prostate cancer in carefully selected individuals who are at potentially high risk for prostate cancer, despite the fact that the FDA denied a formal approval of dutasteride for use in this indication. The ?archiving? of the joint ASCO/AUA guidance document is probably (as much as anything else) a way for the two organizations to protect themselves legally from possible future accusations that they continue to ?recommend? the use of 5-ARIs for chemoprevention of prostate cancer. We do, after all, live in a highly litigious society.
The evidence regarding the actual effect of 5-ARIs in the prevention of prostate cancer and the risk that this use of ARIs may actually increase risk for high-grade prostate cancer is still debatable and controversial, with strong opinions on either side of the issue.
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Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk
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